This guide covers the Powerful Anti-Venom craftable item from the First Aid secondary profession in the mmorpg World of Warcraft, reflecting any and all changes made with the release of Cataclysm and the shattering of Azeroth (patch 4.0.3). You can see additional pictures of this item and recipe by clicking the numbers by the thumbnail above.
Powerful Anti-Venom is the more powerful version of the crafted item Strong Anti-Venom, being able to cure up to an additional 25 levels higher in poisons, up to level 60. Each crafting of this item, unlike the weaker anti-venoms, actually yields 1 Powerful Anti-Venom as opposed to 3, which is important to take into account when purchasing or farming the required materials. As of patch 4.0.3 there is no First Aid craftable upgraded version of this item to cure poisons over level 60.

World of Warcraft First Aid Crafted Items: Powerful Anti-Venom
Requires First Aid 300; Item Quality Normal (White)
Item level 26; Sell to vendor price: 5 Silver, 0 Copper
Estimated auction house buyout price: 50 Silver, 0 Copper (possibly higher, very little market data as item is incredibly rare in AH)
Use: Target is cured of poisons up to level 60 (1 minute cool down)
Item ID: 19440, First seen in WoW version 1.11.1

World of Warcraft First Aid Recipe: Formula Powerful Anti-Venom
This recipe is sold by Argent Dawn and Argent Crusade Quartermasters for 10 Gold (must be Honored).
Use: Teaches you how to make Powerful Anti-Venom.
Average auction house buyout price: 99 Gold, Sell to vendor price: 2 Silver, 25 Copper
Requires First Aid (300) to learn and craft, Crafting time: 3 seconds
Recipe reagents: Huge Venom Sac (x1)
Spell ID: 23787; Recipe Item ID: 19442

Vendors That Sell Recipe: (Zone, Name, Affiliation, Coordinates and Location)
Eastern Plaguelands, Quartermaster Miranda Breechlock, Argent Crusade, Light’s Hope Chapel 75.8-54.0
Trisfal Glades, Argent Quartermaster Hasana, Argent Dawn, The Bulwark 83.2-68.1
Western Plaguelands, Argent Quartermaster Lightspark, Argent Crusade, Chillwind Camp 42.8-83.8

Chance to gain skill points by crafting (this chance scales -1.6% for each level past 300)
Skill Level 300: 100% chance to gain a skill point. Skill Lvl 310: 83.3%, Skill Lvl 320: 66.6%, Skill Lvl 330: 50%, Skill Lvl 340: 33.3%, Skill Lvl 350: 16.6%, Skill Lvl 360: 0%

The average cost of reagent materials is 17 Silver, 0 Copper when purchased through the Auction House. With the vendor sell price for Powerful Anti-Venom of 5 Silver, 0 Copper, this means making this item causes you to lose an average of 12 Silver, 0 Copper per item, strangely enough making this a much cheaper alternative to leveling your First Aid than bandages in this skill range. There is not enough market data to provide a good estimate of profitability for the auction house and it may be hard to find buyers since many might not be looking for, or aware of Powerful Anti-Venom.